![]() Consistently across both studies, we find transcriptional activity explains a substantive proportion (78% and 26%) of the estimated effect of early life disadvantaged social exposures on levels of adulthood inflammation. To address this, we explore the relationship across social-to-biological layers of early life social exposures on levels of adulthood inflammation and the mediating role of gene regulatory mechanisms, epigenetic and transcriptomic profiling from blood, in 2,329 individuals from two European cohort studies. Little is known about the mechanisms linking early life experiences to the functioning of the immune system in adulthood. ![]() Individuals experiencing socioeconomic disadvantage in childhood have a higher rate of inflammation-related diseases decades later.
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